Precision health is a unified approach to match a full range of promotion, prevention, diagnostic, and treatment interventions to fundamental and actionable determinants of health; to not just address symptoms, but to directly target genetic, biological, environmental, and social and behavioral determinants of health. Precision health approaches use advanced computing tools to achieve these goals. Events of 2020, including the COVID-19 pandemic, brought into the vernacular the concept of precision public health, which concerns the use of data and technology to improve public health equity, policy, and practice.